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Ordinarily, patient survival data is derived from a censoring analysis in which the survival time of each patient must be estimated and often, many of the cases have limited follow-ups spaced at longer intervals.
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Whereas each of these processes described above has been shown to occur in nature and therefore contribute to genetic diversity, the phenotypic outcome and importance of each of these processes is hard to estimate and often also depends on the exact environmental conditions.
One woman in 10 of reproductive age has endometriosis, it is estimated, and yet often their primary care doctors do not know what it is and the specialists to whom they are sent are ill-informed.
The model above has a number of parameters to estimate, and is often fitted using maximum likelihood methods under suitable identifying restrictions.
Human mercury (Hg) exposure from seafood consumption and its attendant risks are difficult to estimate and are often the subject of intense debate.
Mortality ratios are often estimated and policy decisions made without robust evidence.
However, an appreciation of costs, price points, market size and profit margins can often be estimated and planned for.
Membership has been difficult to evaluate more recently; church officials give different estimates and often define membership differently, according to an individual's level of involvement.
Therefore, the learning of the proposed approach suffers from noisy estimates and often exhibits some excess mean squared error in relation to the optimal MMSE solution.
The impact of vertical GSHP systems on groundwater and the resulting impairments are difficult to estimate and damage most often cannot be quantified (AD-HOC-AG Geologie 2011).
Furthermore, number of replicates is usually small and estimated variances often differ largely from the true value.
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