Pooling will be conducted in R (www.rproject.org) using the meta package and the degree of heterogeneity between the study-specific estimates will be assessed by I. Table 3 gives a ghost table for the main results.
The accuracy of the image-free navigation procedure for cup and stem placement and the surgeons' intraoperative estimates will be assessed by comparing the intraoperatively acquired implant positions with component measurements on the postoperative CT data sets.
GFR may directly affect serum biochemical markers, therefore estimated GFR (eGFR) will be assessed concurrently with other biochemical markers.
Furthermore, used packaging will be collected to estimate compliance, adverse events will be assessed and glycaemic control will be evaluated at each visit from week 1.
At visits 1 7, used packaging will be collected to estimate compliance, adverse events will be assessed and glycaemic control will be evaluated.
Let us denote as v i pred and v i real the predicted and actual parameter values used in the simulations, where i runs between 1 and N p. The mismatch between estimated and true parameters will be assessed on the log-scale.
A total of 4,000 school children, aged 7 to 15 years, living in the District of Eloy Alfaro and 2,500 children of the same age range, living in the city of Esmeraldas, will be assessed to estimate the frequency of atopy and allergic diseases, including asthma, rhinitis and eczema, and identify and compare risk factors associated with these outcomes in urban and rural study populations.
Cardiovascular fitness will be assessed by estimating VO2 max with PACER (Progressive Aerobic Cardiovascular Endurance Run) scores.
The balance between costs and effects will be assessed by estimating the incremental cost per QALY gained (ICER) for the intervention group compared with the control group.
