We performed trial sequential analysis to account for sparse data and repetitive testing on accumulating data and found that the 95% confidence intervals of the point estimates widened and the results supported those obtained in the conventional meta-analyses.
The difference between the old and new estimates widens each year.
This is not because we used compensating variation (CV) rather than MRS; MRS calculated from our data were 1.5 to 2 times larger than our CV estimates, widening the difference with Sculpher et al 's (2004).
The loss estimate was widened from 10 cents after Toys RR" Us cut its forecast in July.
The loss edged past Wall Street analysts' estimates, but widened from the first quarter and stood in stark contrast to the profit of $423 million, or 13 cents, reported in the period the previous year.
Because light does not reach the floor of most of the caves, perhaps they extend much deeper than these lower estimates and widen below the surface.
This month, the retailer estimated a widening net loss of $105 million, or 95 cents a share, for 2013, compared with a loss of $37 million, or 35 cents, a year earlier.
This reduced the significant associations to null, altering the effect estimates and widening the confidence intervals.
This includes 2009 and 2012, even as the NHC widened their estimate ranges in 2009.
Amazon.com fell 8.6% after Merrill Lynch analyst Henry Blodget widened his estimate for Amazon's 2001 losses.
