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These simulations, typically used by the pharmaceutical industry, for example Sanofi-Aventis, are based on the description of atomic energies to estimate the interactions between a ligand and a protein.
RSM, which includes factorial design and regression analysis, can be used to build models to determine relationship, select the optimal conditions of the variables for a desirable response, and estimate the interactions between a set of controlled experimental factors (Muntari et al. 2012).
First, we resort to niche theory in order to quantitatively estimate the interactions between viral variants constituting a quasispecies.
It is hard to estimate the interactions between the dominant and imprinting effects unless an extremely large sample size (> 2000) is used.
This could be explained by having insufficient statistical power to accurately estimate the interactions between the different complications when estimating the risk equations.
To examine whether growth rates of nutritional status differ between children left behind at different stages of childhood compared to children from intact families, we estimate the interactions between the left behind stage variables and children's age (linear and quadratic terms).
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A univariate general linear model was used to estimate the interaction between diabetes, stenting, and hospitalization costs.
Since tobacco is a well-confirmed inducer of DNA damage, in particular DSBs [ 35], we performed stratified analysis to estimate the interaction between the genotypes and smoking status.
Because regression analyses of the total study group (boys and girls) were applied to estimate the interaction between exposure and sex, the p-values for only the interaction terms are given in "Results".
These were used to estimate the interaction between treatment effect and EGFR mutational status, calculated as the ratio of the estimated HRs within the EGFR wild type subgroup and the EGFR mutation subgroup for each trial.
We performed stratified analysis to estimate the interaction between miRNA processing genes single nucleotide polymorphisms and cigarette smoking (Tables 6 8, Supplementary Materials available online at http://dx.doi.org/10.1155/2015/298378).org/10.1155/2015/298378
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