Nevertheless, and in spite of using complete genome data, our current estimates should be viewed with caution.
Although our approach adopts recognised statistical adjustment techniques [ 21], these estimates should be viewed cautiously due to non-response.
Because of the large uncertainties, the costs estimated should be viewed only as indicators of the relative magnitude of health adaptation costs.
Because our metric is more stringent than bi-directional best BLAST hits, which is used in many publications, these estimates should be viewed as a conservative estimate in comparison.
Tumor growth estimates may also be affected by HRT use, and both the STS and tumor growth estimates should be viewed in the light of the relatively high HRT use during the study period.
They concluded that there were large differences in evolutionary rates of reptilian hemoglobins between larger groups, causing an erroneous topology, so their age estimates should be viewed with caution.
Given these issues and the relatively small sample size on which the quantitative estimates were based, these estimates should be viewed as an initial indication of the potential impacts that can reasonably be expected if coordinated efforts by public and private stakeholders are successful.
It is important to note that the use of the three shallow level calibration points available under the restrictions of our data set constitutes a likely source of variation in our divergence time estimates, especially at deep nodes very distant in time from the calibrated nodes [ 65], so all of these estimates should be viewed with caution (See [ 18]).
Consequently, the C. porosus copy number estimate of 19,754 should be viewed as a minimum number of CR1a/b elements, not total CR1 elements, in the C. porosus genome.
For this reason, their cost-effectiveness estimates for PCV13 should be viewed with great caution.
