This number gives an estimate of the potency of a specific mutagen and in this study also served as a baseline of mutagenesis.
When the U.S. Environmental Protection Agency EPAA) finalized its 2000 update of the toxicological effects of vinyl chloride (VC), it was concerned with two issues: the classification of VC as a carcinogen and the numerical estimate of its potency.
While this in vitro assay gives a crude estimate of the potency of individual ESCs, it is difficult to assign totipotency based solely on marker expression in the absence of embryonic context.
Second, the estimate of cancer potency was reduced 10-fold from values previously used for environmental decision making, a finding that reduces the cost and extent of pollution reduction and cleanup measures.
This was then used to estimate potential potency of the inhibitor for its anti-angiogenesis effect.
The TEF approach is a relative potency paradigm that is based on estimates of the potency of dioxin-like effects of individual chemicals, or a mixture of chemicals assuming a common mechanism of action involving binding of the compound(s) to the aryl hydrocarbon receptor (AhR) (Schmidt and Bradfield 1996).
But they have redefined estimates of its potency and reach, saying that the American-led war in Afghanistan badly disrupted the group's leadership and forced Mr. bin Laden and his top lieutenants to turn to new operational leaders.
Individual estimates of the potency ratio for R-albuterol/RS-albuterol were calculated and summarized across all subjects.
Our studies offer a measure of the magnitude of this error that in turn contributes to the variability of the biological effects expressed in concentration response relationships and estimates of functional potency.
Individual concentration response curves were fitted to a Hill-type model giving estimates of agonist potency (EC50) and efficacy (Emax).
Such parameters may be useful as quantitative estimates of the potency of hepatocarcinogenic agents not only in rodents, but potentially in quantitative risk estimations in the human.
