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This number can be used to obtain a crude estimate of mutation rate (see " Methods").
The within-patient estimate of mutation rate does not have the same measurement problems and gave a consistent result.
In order to convert IM estimates into biologically meaningful values (effective population sizes, divergence times in years or migration rates) one needs an estimate of mutation rate.
Inclusion of an estimate of mutation based on a sample size of one should be clearly inadequate to anybody including Amos!
One option is to constrain θ to be proportional to an independent estimate of mutation rates or a proxy such as interspecific synonymous nucleotide divergence.
This value corresponds well with an estimate of mutation rate for microsatellite loci in Cyprinus carpio of 5.56 × 10-4 [ 60] and a mean mutation rate of ca. 10-4 for microsatellites in humans [ 61].
Similar(45)
For example, our estimates of mutation bias and those from mutational accumulation experiments are highly correlated (ρ = 0.95 ).
Given the absence of known fossils, estimates of mutation rates are very limited and uncertain in macroalgae and our estimation of the time of divergence between M. laminarioides lineages should be taken with caution and as a heuristic tool.
Until recently, good estimates of mutation rates have been hard to come by.
Better estimates of mutation rates in these viruses are needed.
Recent measurements of the molecular clock for mitochondrial DNA reported a value of 1 mutation every 7884 years dating back to the most recent common ancestor of humans and apes, which is consistent with estimates of mutation rates of autosomal DNA (10−8 per base per generation ).
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