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There were 327 cases with missing data for the residency variable, this could have led to an incorrect estimate of differences.
We therefore report the estimate of differences compared with the control group with their 95% confidence intervals.
In the following we will use differences in relative read abundances between metagenomes as an estimate of differences in relative DNA amounts in the sample.
Differences in the health services can be assessed using hierarchical models, including variables at hospitalization and hospital levels, allowing the estimate of differences in outcome not fully explained by observed patient or other specific and known conditions.
Differences in principal referral outcomes between arms are thus an unbiased estimate of differences between the two overall service models, except for the timing of consent, the effect of which we believe would be small and not create any systematic bias.
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In addition, the percentages of ACR 50 and 70 responders were numerically higher with abatacept vs infliximab treatment (with overlapping 95% CIs for the estimate of difference for ACR 50: 45.5 vs 36.4%, estimate of difference (95% CI) = 9.1 (–20.5 20.5); ACR 70: 26.3 vs 20.6%, estimate of difference (95% CI) = 5.7 (–4.2, 15.6), respectively).
Differences across replications were consistent in direction, but varied somewhat in the estimate of difference between the wild type and bmr mutant.
This is considered to be a conservative estimate of difference and is based on the published minimal important difference for the AQoL instrument.
The parameter estimate of difference in cortical thickness between AD and OC was then used to generate a map of the magnitude of cortical thinning in AD.
Discontinuations due to AEs occurred in 3.8% versus 9.5% of the abatacept and adalimumab patients (estimate of difference −5.7 (95% CI −9.5 to −1.9)).
Discontinuations due to SAEs occurred in 1.6% versus 4.9% in the abatacept and adalimumab groups (estimate of difference −3.3 (95% CI −9.5 to −1.9)).
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