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Finally, the proposed methodology is demonstrated by using reported statistics on the placebo arms from several recently published symptomatic trials on AD to estimate necessary parameters and then deriving the optimum sample sizes and the time of treatment switch for future DM trials on AD.
Based on the micro-simulation, we estimate necessary return-to-work conditions for different types of individuals.
First, we determined a hypothetical effect estimate necessary to shift our meta-analysis under two scenarios: a) that the 95% CI of the meta-analysis overlaps zero (becomes statistically insignificant), and b) that the meta-analysis effect estimate is greater than zero (moves in the opposite direction).
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Predictive models such as Universal Soil Loss Equation (USLE) and its subsequent Revised Universal Soil Loss Equation (RUSLE) are useful tools to generate the quantitative estimates necessary for designing sound conservation measures.
This change of the problem setting is useful for obtaining of a priori estimates necessary for the application of the Fredholm-type existence theorem (Lemma 5.5) during the proof.
We suggest that subjects adjusted their movement termination by rotating the learned but curved trajectory and the state estimates necessary to achieve accurate termination at the new location.
Walsh [ 38] estimated necessary sampling values of > 50 individuals in order to perform well with PAA.
A total of 400 patients were estimated necessary to obtain at least 100 exploitable observations in each treatment group at M6 (6 months).
Although PLD was used with the aim to increase dose intensity of doxorubicin, the doses evaluated so far, are lower than those estimated necessary for optimal response compared to doxorubicin.
The simulation model was shown to be valid and suitable for the provision of accurate benefits and risks estimates necessary for the refinement of screening guidelines in these women.
The study employed NIH-endorsed research methods for a stage-1 behavioral therapy program development [ 58] with identified outcomes of exploring treatment acceptability and adherence and establishing initial efficacy estimates necessary to guide future research.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com