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If there were data for 10 to 19 days, the number of headache days for the missing period was imputed by taking the average of the 2 estimates (the mLOCF estimate and the prorated estimate for the data recorded).
Although we acknowledge that this estimate possibly differs from a multivariate estimate for the data matrix as a whole, it is as yet not possible to estimate such parameters for multivariate data sets.
The Intraclass correlation 1, ICC(1), estimate for the data indicated that a degree of agreement existed around the group (unit and nursing home) mean for the CRU scale score (ICC1 =.1352 and.1354 when scores are aggregated to unit and nursing home levels respectively).
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The mean log likelihood was estimated for the data for a given k (referred to as L K)) in each run.
The ML tree was also estimated for the data with the indels treated as missing data (not coded) (Additional file 1: Figure S1), for comparison with Figure 4.
For maximum likelihood and Bayesian analyses, a model of sequence evolution was estimated for the data set using MODELTEST ver. 3.7 [ 37].
Linkage disequilibrium was estimated for the data set from the Ishigakijima Island population and was found to be not significant between any loci (P < 0.01).
Regression modelling where separate coefficients are estimated for the data segment preceding and succeeding an intervention—'segmented regression' is a commonly used ITS method.
Therefore it is essential to examine the distributions of the covariates requiring imputation to determine whether transformations are likely to provide reasonable estimates for the data to be analysed.
To evaluate the effect of data from each country on the summary estimate for the pooled data, we excluded countries from the INWORKS cohort one at a time.
Models are based on random errors corrected for autocorrelation estimated from the data by the Joinpoint Program.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com