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Meta-analysis was performed using the two randomised studies plus (i) the unadjusted estimate from the non-randomised study and (ii) the reported adjusted estimate, adjusted for baseline differences in the groups.
StarMine's SmartEstimate (an estimate adjusted for the accuracy and timeliness of the contributing analysts) for J.P. Morgan Chase stands even lower than the consensus number.
As a last step, we incorporated random error to obtain an OR estimate adjusted for exposure misclassification and random error.
The overall estimate adjusted for age and sex was 1.32 (95% confidence interval 1.08 to 1.62) without the Women's Health Study (data not shown in the figure).
Estimate adjusted for age at menarche (continuous), age at first birth (continuous), age at first birth (continuous), alcohol consumption (ever/never) and HRT use (ever/never).
The trim and fill method then provides an estimate of an intervention effect estimate adjusted for the assumed publication bias and the 'missing' trials are plotted.
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A revised pooled estimate "adjusting for publication bias" is then derived from this reduced dataset.
Our analyses were based on most-adjusted RR estimates, with many of the estimates adjusted for other aspects of smoking, such as number of cigarettes smoked.
Multivariable adjusted estimates were based on meta-analysis of estimates adjusted for demographic and lifestyle covariates (see supplementary table S4 for details).
Estimates adjusted for place of birth and year of diagnosis (A), with additional adjustment for lymph node status (B) and tumour diameter (C).
If effect estimates adjusted for potential confounders were not presented the authors were contacted with a request for adjusted data.
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