Adverse effects (periodontal problems) See comments Relative effect (95 % CI): not estimable 10 (1 study, SP) ⊕⊕⊝⊝f Low There was no significant difference in mobility scores of canines between the control and experimental groups pre- and post-distalization (p > 0.05).
Adverse effects (unwanted tooth movement) See comments Relative effect (95 % CI): not estimable 18 (1 study, SP) ⊕⊕⊝⊝g Low There was no significant difference between control and experimental sides for canine tipping and rotation (p > 0.05).
Pain and discomfort See comments Relative effect (95 % CI): not estimable 10 (1 study, COMP) ⊕⊝⊝⊝d Very low The difference between the control and experimental groups was not significant (p > 0.5) at 1, 7, 14 and 28 days after retraction.
Adverse effects anchorage loss See comments Relative effect (95 % CI): not estimable 10 (1 study, SP) ⊕⊕⊝⊝f Low There was significant difference in loss of anchorage between control and experimental groups (p < 0.05), the anchorage loss was lesser in the piezocision group.
Relative effect (95 % CI): not estimable 28 (2 studies SP) ⊕⊕⊝⊝a Low This outcome also measured at 1 month in 3 studies (38 patients): mean canine retraction in the intervention groups was 0.65 higher (0.54 to 0.76 higher) with a quality of evidence very low ⊕⊝⊝⊝b.
However, any one-parameter straight line model, such as the proposed proportional hazards model, is estimable within each study, although within-model diagnostics is limited since we are fitting the full within study model.
It was assessed whether the underlying parameter values of the model are estimable from these studies, and the precision of the parameter estimates were calculated.
However, with innovative and creative design, the independent and joint effects of multiple pollutants should be estimable in epidemiologic studies.
The first concerns the assumption that the sharing of the monozygotic twins' environment is identical to that of dizygotic twins an assumption necessary for heritability to be estimable from twin studies.
High protein supplementation in pregnancy was associated with a non-significant reduction in stillbirth [ 114] (RR = 0.81, 95% CI: 0.31 2.15); the effects of isocaloric balanced protein-energy supplementation in pregnancy was non-estimable because the study reported no stillbirths in either group [ 115].
