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The appropriate delivery of [3H]-cholesterol to the liver may have been hampered by reduced cholesteryl ester transfer from HDL to LDL/VLDL particles, as suggested by reduced plasma CETP mass (1.74±0.12 vs. 1.38±0.12, control vs. T-0681, P = 0.07).
Most likely the reduction in cholesteryl ester transfer from HDL that results in elevation of HDL-C is governed by the degree of reduction in VLDL [ 24].
Rabbits treated with SR-BI-specific plasmid-complexes displayed higher cholesteryl ester transfer from HDL to apoB-containing lipoproteins, lower HDL-cholesterol, and higher VLDL-cholesterol levels, when compared to controls.
Several metabolic processes may contribute to these low HDL levels: decrease in free cholesterol removal from cells, low cholesterol esterification rate and high cholesteryl ester transfer from HDL to apo-B containing lipoproteins [ 47].
The correlation between declines in LDL4 cholesterol and increases in HDL cholesterol found in our study may indicate specific attenuation of cholesteryl ester transfer protein mediated cholesteryl ester transfer from HDL to small, dense LDL.
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Through the action of cholesterol ester transfer protein, TGs are transferred from VLDL to HDL, creating TG-rich HDL particles, which are hydrolyzed by hepatic lipase and rapidly cleared from plasma (5).
Cholesterol ester transfer protein transfers TG from TG-rich lipoproteins to HDL [ 30].
HDL also exchanges lipids with VLDL and LDL in a process involving cholesteryl ester transfer protein (CETP), whereby cholesteryl esters are transferred from HDL to VLDL and, reciprocally, triacylglycerols are transferred from VLDL to HDL.
The human cholesteryl ester transfer protein (CETP) transfers cholesteryl ester from high-density lipoprotein (HDL) to other lipoproteins and has been established as an attractive target for reducing the risk of atherosclerosis.
In humans, cholesterol is mainly transported in LDLs whereas in mice cholesterol is carried almost exclusively in HDLs, mainly due to the fact that mice lack cholesterol ester transfer protein (CETP), which transfers cholesterol from HDLs to LDLs.
The most likely explanation is a reduced rate of cholesteryl ester transfer protein (CETP -mediated flow of CETP -mediatedom HDL.
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