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Chandrasekhar, I., Oostenbrink, C. & van Gunsteren, W. F. Simulating the Physiological Phase of Hydrated DPPC Bilayers: The Ester Moiety.
The mild reaction conditions prevented undesired polymerization and hydrolysis of the acrylate ester moiety.
The presence of the F atom on the ester moiety at the position 8 was crucial.
The ion selectivity is very sensitive to the structure of polyoxyethylene spacer and the R in the ester moiety.
About 86% of the samples still consisted of tienoxolol and the main impurity (13%) was caused by the hydrolysis of the ester moiety.
Preliminary structure activity relationship (SAR) studies with these compounds revealed the importance of the ethyl ester moiety on the amino acid moiety.
The docking results suggested that these alkenyl derivatives containing ester moiety interact well with the PDE4B protein in silico where the ester carbonyl oxygen played a key role.
The preliminary structure−activity relationship (SAR) revealed that the replacement of 9-methoxyl with an ester moiety might significantly enhance the antiproliferative activity in vitro.
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As peptides containing sulfo-tyrosines are difficult to synthesize and handle due to limited stability of the sulfo-ester moiety, we have now incorporated TYS isosteres into CCR5 Nt analogs and assessed their binding to a complex of gp120 CD4 using saturation transfer difference (STD) NMR and surface plasmon resonance (SPR).
As peptides containing sulfo-tyrosines are difficult to synthesize and handle due to limited stability of the sulfo-ester moiety, we have now incorporated TYS isosteres into CCR5 Nt analogs and assessed their binding to a complex of gp120-CD4 usaturationatransfernsfer difference (STD) NMR and surface plasmon resonance (SPR).
A first compound, SA-17, identified as a potent inhibitor of flavivirus replication, is an analogue of doxorubicin (an antineoplastic antibiotic from Streptomyces peucetius) that carries a squaric acid amide-ester moiety at the carbohydrate (α- l-daunosaminyl) of doxorubicin.
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