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Recently, topline results from the ESTEEM 1 trial were presented [ 39].
Apremilast was compared with placebo in ESTEEM 1 and 2 [ 15, 16] and with etanercept and placebo in LIBERATE [ 17].
A significant and consistent decrease in pruritus with apremilast 30 mg BID compared with placebo was reported as early as week 2 in both ESTEEM 1 and 2.
The proportions of patients achieving a PPPGA score of 0 1 at week 32 in ESTEEM 1 have not yet been published.
In ESTEEM 1 and 2, serious AEs (serious infections, malignancies, and cardiovascular events) and laboratory test value changes were consistent with those reported in previous apremilast studies.
In ESTEEM 1, the time to loss of PASI improvement and loss of PASI-75 response were evaluated at 52 weeks.
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Moreover, the case has previously been made that dispositional affect is related to self esteem [27].
The majority of AEs in ESTEEM 2 were also mild or moderate in severity.
Dr. Melinda Gooderham was an investigator for ESTEEM 2 and LIBERATE, sponsored by Celgene Corporation.
The reward scale consists of three subscales: esteem (5 items); job promotion (4 items); job security (2 items).
Participants then completed a measure of state self-esteem using the single-item self-esteem scale previously developed and used by Robins, Hendin, and Trzesniewski (2001): At the moment I have high self-esteem (1 = strongly disagree to 6 = strongly agree).
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