In addition, the establishment of protein and CLC interactions may strengthen the interactions that stabilize the protein net.
An establishment of protein targets characteristic of LCNEC is quite helpful for decision of optimal therapeutic strategy by diagnosing individual patients.
Moreover, the establishment of protein labeling methods has enabled the quantitative measurement of proteins and peptides in samples on a proteome-wide scale [5], [6].
Gene ontology analysis for the 3415 transcripts with male biased expression found over representation in the cytoplasm cellular component (p = 0.001), and the biological processes of protein transport, localization, and establishment of protein localization (all p<0.05).
These gene sets included the GO: endomembrane system, endoplasmic reticulum, transport, establishment of protein localization as well as the KEGG pathway SNARE interactions in vesicular transport (Supplemental Figure S1A).
In order, from most to least commonly represented, these were signal transduction, intracellular signaling cascade, cell organization and biogenesis, protein localization, protein transport, establishment of protein localization, transmission of nerve impulse, small GTPase mediated signal transduction, synaptic transmission and vesicle-mediated transport.
The high dynamics of the α-helices, which face the DNA in the PCNA-loaded form, is likely to have functional implications for the sliding of the PCNA ring on the DNA since a large hole with a flexible wall facilitates the establishment of protein-DNA interactions that are transient and easily broken.
To investigate the contribution of gene duplication to the establishment of protein complexes, we examined portions of duplicated genes (proteins) or paralogs in the complexes.
Components for the establishment of protein-protein interactions with other components of the eukaryotic transcriptional machinery have been detected in the N-terminal module [ 12- 14].
It is noteworthy that also the terms "protein transport" and "establishment of protein localization" were those with a higher significance and shown to be under-represented.
In addition, this study underlines the importance of an internal salt bridge for protein conformation and thus for the establishment of protein-protein interactions between MYB and bHLH transcription factors.
