However, these RNAi results do not clarify whether this Wnt-Cad organiser is still required during germ band elongation, or whether the phenotypes observed arise secondarily from earlier defects during establishment of the GZ.
Interestingly, during the establishment of planar hair cell polarity, defects in cell-surface microtubules have been shown to lead to kinocilium/basal body mispositioning and improper bundle morphology and orientation (Sipe and Lu, 2011; Sipe et al., 2013, Ezan et al., 2013).
Because strong depletion of any of these proteins results in polarity establishment defects, loss of cortical contractility and cytokinesis failure, we used partial depletion conditions under which PAR domains were able to form by the onset of anaphase.
Some of these projects, such as the establishment of local rehabilitation centers for defecting low-level Taliban fighters, demand urgent investments, within months.
The Prdm14−/− mice failed to develop embryonic germ cells due to a defect in establishment of a pluripotent state and a failure to reset the epigenetic programming in primordial germ cells.
It suffered, however, from sometimes vicious factionalism among officials, recurrences of abusive influence on the part of palace eunuchs, and defects in its establishment of hereditary soldiers.
Head, brain and craniofacial dysmorphisms point to defects in the establishment of body plan symmetry [22], [28].
We here evaluated whether Te-0 resistance may result from defects in the establishment of compatibility.
In rice, a mutation in SHOOTLESS2 (SHL2) causes defects in the establishment of anther adaxial/abaxial polarity (Toriba et al. 2010).
This result suggested that disruption of germ cells migration results in defects in the establishment of the initial (neonatal) SSC niche, eventually leading to impairment of SSC function.
A multiplicity of considerations bear upon the establishment of causality and, especially regarding birth defects, epidemiological inference relies on input from a variety of other disciplines.
