Long-term records enable establishment of databases, which would illustrate bird-pathogen relationships in natural conditions.
Importantly, the advancement of technology has led to the establishment of databases of transcription factors (TF) and transcription factor binding sites (TFBSs).
The establishment of databases have been supported by top-management decisions and sufficient resources made available for software development and presentation.
The opportunity to decipher the mechanisms underlying cellular physiology from the analysis of molecular interaction networks has prompted the establishment of databases devoted to the collection of such data, with great attention to protein and genetic interactions (19 22).
The DD2 project will consist of two parts: a large population-based prospective cohort study including the establishment of databases and a biobank that will allow a number of ensuing nested case-control studies and clinical intervention.
In recent years, the Human Genome Project and related efforts have led to the establishment of databases based on genomics and transcriptome analyses, and transcriptional profiling and high-throughput technology using microarrays have been applied to systemic drug screening.
Next-generation sequencing on large human populations could now enable the establishment of databases documenting allele frequencies of genetic variants, and such databases can provide a platform to separate very rare variants (potentially causal for Mendelian diseases) from low-frequency polymorphisms.
The establishment of databases of LoF variants, together with careful evaluations of the known functional evidence in the context of the phenotypes of interest, will be required to determine if a gene with LoF mutations is truly causal, at least within particular genetic backgrounds.
This has resulted in the establishment of databases such as the Online Mendelian Inheritance in Man (OMIM) [ 4], where it is possible to access data regarding a gene or gene product and browse through the information of how different mutations are associated with reported phenotypes.
Here we report recent updates to the LIPS database and the establishment of a database table, LIPService.
