The development of the CDSS followed two steps: establishment of the concept and proof of concept (figure 1).
Experimental studies have been fundamental in the establishment of new concepts regarding the mechanisms underlying the ischemic brain injury, such as the ischemic penumbra, the reperfusion injury, the cell death or the importance of the damage induced on mitochondria, glial cells and white matter.
In this review we see that solid foundations of basic molecular research are required, not necessarily for establishment of therapeutic concepts, but for development of therapies towards safe and effective clinical treatments.
At the Seventeenth National Congress of the CCP in 2007, President Hu Jintao again called for the establishment of the concept of socialist rule of law.
The establishment of this concept creates a new perspective on the pathophysiology of T2D and other age-dependent disorders.
These findings led to the establishment of the concept of "ground state pluripotency," where differentiation cues are shielded, and the pluripotency network is intrinsically stable (Nichols and Smith, 2009; Ying et al., 2008).
The ISCEV Keynote Lecture, "The cellular origin of different components of the electroretinogram", was presented by Prof. Trevor Lamb and the prestigious Emiko-Adachi Lecture, entitled "Establishment of the concept of new clinical entities complete and incomplete CSNB and occult macular dystrophy", was delivered by past ISCEV President, Prof. Yozo Miyake.
This evidence has led to the establishment of the concept for the tripartite synapse (Araque et al., 1999; Perea et al., 2009), which represents a novel functional view of synaptic physiology where astrocytes are relevant elements actively involved in synaptic function and neurophysiology.
