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The establishment of a functional vasculature is as yet an unrealized milestone in bone reconstruction therapy.
The successful clinical outcome of the implanted tissue-engineered bone is dependent on the establishment of a functional vascular network.
Small bioengineered liver constructs have been developed, however a major challenge in achieving functional bioengineered liver in vivo is the establishment of a functional vasculature within the scaffolds.
This review summarizes current understanding of the mechanisms leading to the establishment of a functional coronary collateral network and the biological processes growth factor therapies should stimulate even under conditions of impaired natural adaptive vascular response.
Many studies have shown that the full establishment of a functional cardiac tissue in vitro requires synergistic actions between the seeded cells, the tissue culture condition, and the biochemical and biophysical environment provided by the biomaterials-based scaffolds.
Thus, this study indicates that incurring high costs for the establishment of a functional cost system might be justifiable, on condition that the firm will utilize the obtained cost data through various decision-making tools; otherwise there is no point in bearing the cost of building such a system.
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Such animals display a severe muscular dystrophy and a profoundly impaired regenerative capacity that is restored by re-establishment of a functional basal lamina 39.
This is addressed in the present study in an attempt to promote the re-establishment of a functional detour around a hemisection (Hx).
Overall, these data support the notion of profound plastic alteration of the corticostriatal connection after DA depletion and L-dopa treatment and further suggest that the apparent normalization in the number of dendritic spines is actually not normalization but reflects the establishment of a different functional situation.
In this issue of Ebiomedicine, Wang et al. (2015) describe the establishment of a comprehensive functional database for nematode intestinal proteins.
Establishment of a gene functional association networkThe fact that cell passage dependent gene expression in both HUVEC and NHDF cells influences angiogenesis supports modeling the angiogenesis network using the DEGs identified by these DNA microarray experiments.
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