However, precisely how these factors control the chronology of enhancer establishment during differentiation is not known.
With the establishment of differentiation in the developing embryo, the mitochondrial complement both diversifies and amplifies depending on the cell type.
Following the establishment of differentiation, cells almost never change their 'epigenetic state' or revert to a gene expression state typical of an earlier stage of less differentiation.
One approach needs to use mutant mice to delineate the molecular basis of developmental mechanisms that govern ear development, including formation and differentiation of neurons and establishment of their peripheral and central connections.
The establishment of cardiomyocyte differentiation of embryonic stem cells (ESCs) is a useful strategy for cardiovascular regenerative medicine.
Most miRNAs were expressed in a highly tissue-specific manner during segmentation and later stages, but not early in development, which suggests that their role is not in tissue fate establishment but in differentiation or maintenance of tissue identity.
These patterns are consistent with single, relatively recent introductions followed by widespread dispersal, ecological establishment, and local differentiation.
Each ovariole contains two or three germline stem cells, which are in contact with somatic cells that regulate their establishment, maintenance and differentiation.
For this reason, discovery of new anti-taeniosic drugs should be aimed to restrain differentiation, establishment, and egg production of the T. solium adult intestinal tapeworm.
Many efforts have been focused in these last years on the disclosure of the miRNAs involved in the establishment of myeloid differentiation and leukemogenesis.
Taken together, the major factors possibly affecting leaf rolling include the alteration of osmotic pressure and/or turgidity in bulliform cells, the impairment of cell polarity establishment and cell differentiation.
