Sentence examples for establishment defects from inspiring English sources

In contrast, ELG1 deletion suppresses both ctf7-dependent temperature sensitivity and cohesion establishment defects (this study).

Because strong depletion of any of these proteins results in polarity establishment defects, loss of cortical contractility and cytokinesis failure, we used partial depletion conditions under which PAR domains were able to form by the onset of anaphase.

To assess whether the loading and SCC establishment defects are separable, the predicted CHK kinase phosphosites in COH-3/4 are being changed to alanine.

Thus, cohesin in smc1-D1164E cells had an inherent moderate cohesion establishment defect independent of cohesin regulators.

This would suggest that a G2/M checkpoint establishment defect is not the explanation for the damage sensitivity observed for some rfa2 N-terminal mutants.

This leads us to conclude that either another acetylated histone target of Sir2, such as H3K9Ac or H3K14Ac, a combination of acetylated histone targets, or perhaps an acetylated non-histone chromatin target contributes to the centromeric heterochromatin establishment defect seen in cells lacking Sir2 activity.

This was interpreted as a sign that the electorate was not simply threatening the establishment with defecting to the extreme right.

Problems were still being encountered in July 1943, with a report from the Fighting Vehicle Proving Establishment indicating that serious defects were still being found in the models being tested; the problems became so acute that trials of the Mk VIII were abandoned earlier than scheduled.

However, we did not find defects in establishment or maintenance of the left right asymmetry in mouse embryos with global deletion of integrin αv.

However, these RNAi results do not clarify whether this Wnt-Cad organiser is still required during germ band elongation, or whether the phenotypes observed arise secondarily from earlier defects during establishment of the GZ.

The Prdm14−/− mice failed to develop embryonic germ cells due to a defect in establishment of a pluripotent state and a failure to reset the epigenetic programming in primordial germ cells.