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In Cambridge, Massachusetts, at least, student pranks have become an establishment activity.But the scene of what many consider the best-ever engineering prank was that other academic Cambridge, in England, where, one morning in 1958, the town awoke to see an Austin Seven van on top of the Senate House building.
Here, loss of Elg1-RFC allows for more efficient binding of Ctf18-RFC to ctf7p mutant protein - providing for more efficient cohesion establishment activity.
In combination, these findings reveal that Ctf7p-dependent cohesion establishment activity is highly sensitive to Elg1-RFC dosage and in a fashion that is separate from that of Ctf18-RFC dosage.
This is an interesting finding as it implies that the maintenance activity of DRM2 can be mechanistically distinguished from its de novo methylation establishment activity, suggesting that during the maintenance phase there is another level of regulation of DRM2 activity by histones.
Similar(56)
Given that rad61 bypasses completely ctf7 null cell lethality under these conditions, the finding that rad61 deletion is not sufficient to suppress ctf7 ctf18 mutant cell conditional lethality is consistent with the model that Ctf18-RFC exhibits establishment activities beyond those associated with Ctf7.
But what was funny old Boris doing in Copenhagen this time, if not the extremely cool and anti-establishment activity of lighting up a big fat bifter?
Internet access is already tightly controlled, with many pro-democracy websites banned and the majority of public computers monitored for anti-establishment activity.
Whether the reenactment has truly galvanised the Manchester audience towards a longer term commitment to anti-establishment activity remains to be seen.
Whether the reenactment has truly galvanized the Manchester audience toward a longer-term commitment to anti-establishment activity remains to be seen.
The anti-establishment activity of Elg1-RFC complex is particular intriguing given that an alternate Ctf18-RFC complex exhibits robust pro-establishment activity.
Moreover, our data supports a model that Elg1-RFC anti-establishment activity occurs via regulating Ctf7-dependent Smc3 acetylation.
Related(17)
foundation activity
settlement activity
creation activity
achievement activity
appointment activity
formation activity
implementation activity
deployment activity
attainment activity
construction activity
implantation activity
preparation activity
setting activity
elaboration activity
facility activity
opening activity
plant activity
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com