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Establishing with confidence whether the increase in neurosteroid levels associated with SSRI treatment contributes to the therapeutic action of these antidepressants in humans has proved difficult to assess and remains unclear.
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"There is, inevitably, further work for my colleagues and I to do to evaluate those submissions, which are detailed and substantial, in order to establish with confidence the time needed to complete the Inquiry's remaining work," he said.
Thus, a suggested area of research is on how to use robust experimental evidence to establish with confidence the impact of subsidized health insurance programs on informality and health.
Unless full PK/PD relationships can be determined, the drug target candidate profile for first in class targets cannot be established with confidence; consequently, chemistry strategy cannot be implemented without risks.
Thus, a suggested area for research is on the way to use robust experimental evidence to establish with confidence the impact of subsidized health insurance programs on labor informality and health.
However, the phylogenetic relationships among the tested isolates determined from different methods of analysis are not always consistent and could not be established with confidence.
For example, when the value of a monosomy (or ChrX in a male patient) establishes with confidence the continuous log2 value corresponding to discrete integer copy loss, this signal is often an arm-length loss that falls halfway between diploid and the log2 value of single-copy loss.
Therefore, it is currently unfeasible to establish with confidence the degree to which specific NMDRs are reproducible.
Because of the cross-sectional nature of the study, the temporality of certain associations cannot be established with confidence.
Specifically, an enhancing stalk is seen in many polyps, allowing the diagnosis to be established with confidence (Fig. 7).
Perhaps most clearly here, this definition would require rigorous designs to establish with confidence that a certain modification could certainly lead to harm avoidance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com