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Here we report that AAV2/9-mediated p.A53T mutated human α-syn overexpression induces robust nigrostriatal neurodegeneration in mice, rats and monkeys, establishing translational comparisons among species.
Recently, there has been a move towards establishing translational methods for research into MDD, although the nature of this disease presents challenges for emulating aspects of the disorder in non-human species (see Berton et al., 2012 for a recent discussion).
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The recent discovery of induced pluripotent stem (iPS) cell technology now offers a powerful opportunity to establish translational platforms for cardiac disease modeling, drug discovery, and pre-clinical testing.
Elisseeff also directs the recently established Translational Tissue Engineering Center at Johns Hopkins in collaboration with the university's Biomedical Engineering Department.
Universities and medical schools around the world have established translational research arms in recent years hoping to cash in on basic research discoveries.
After 2006, many other countries and regions started to establish translational research center for translational research.
4 5 12 15 The UK has invested £450 million over 5 years to establish translational research centres including an Informatics Initiative.
The US National Institutes of Health (NIH) has devoted considerable resources to establish translational research centers, hence medical schools and universities have developed many translational research training programs.
Translational research has also become a centerpiece of the European Commission for health related research in 2006, and during which, the United Kingdom invested the most to establish translational research centers [ 14].
Besides academic centers, foundations, industry, disease-related organizations, individual hospitals and health systems have also established translational research programs, and at least two journals (Translational Medicine and the Journal of Translational Mdicine) are devoted to the topic.
We report that under basal conditions, MKRN1 associates with established translational regulators, such as HuR, YBX1, and IGF2BP1 (Table 1), as well as several apoptosis-related transcripts (Fig 8).
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