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To avoid working routinely with 50 μg portions of extremely neurotoxic and expensive BoNT-A (LD50 in humans is about 75 ng [6]), developing and establishing the optimal method of labelling BoNT-A with 125I was done with cetuximab.
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Clearly more research will be needed to establish the optimal method for valuing family spillover effects.
As cartilage regeneration research matures, long-term follow-up and larger comparative trials will ultimately establish the optimal method for cartilage repair.
The interaction binding characteristics were determined and compared to literature data to establish the optimal immobilization method for the TLR3 BRE.
These were tested using resonance fatigue loading to establish the optimal fabrication methods for improving fatigue life.
Future studies are thus required to establish the optimal drug delivery method but also to establish the mechanisms of action and the optimum usage situations for ADAC.
(It has been well established, by statistical study, that the optimal method for taking penalities is simply to blast away in the middle, and the optimal strategy for the goalkeeper is to remain exactly in place exactly at midpoint; the challenge is having the discipline to do it).
The diagnosis of invasive pulmonary aspergillosis is difficult because definitive diagnosis is based on histological documentation of typical hyphae and a culture positive for an Aspergillus sp. Uncertainty in disease definition is a key contributor to the controversy regarding the optimal method for establishing the diagnosis of invasive infection.
Heparin bridging therapy has been used in these situations, although the optimal method has not been established.
Multiple TACE protocols are used throughout the world, and the optimal method is yet to be established.
The optimal method of resuscitation has not been clearly established.
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CEO of Professional Science Editing for Scientists @ prosciediting.com