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Verapamil abrogated the acquisition of chemoresistance (Figure 4C), thus establishing the involvement of MDR proteins.
After establishing the involvement of TLR2 in diet/bacteria induced atherosclerosis, we performed a detailed examination of plaque compositions by immunofluorescence staining.
There are multiple reports establishing the involvement of arsenic in sister chromatid exchange (SCE) and chromosomal aberrations in cultured cells [ 45- 47].
In the presence of efflux pump inhibitor, the MIC to ciprofloxacin decreased from 4 µg/mL to 1 µg/mL, and the MIC to nalidixic acid decreased from >512 µg/mL to 32 µg/mL, establishing the involvement of an efflux pump in conferring quinolone resistance.
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Further investigations were therefore directed to establish the involvement of FOXO3a transcription factor localization and Akt activity, both of which are involved in p21/CDKN1A expression [ 28, 29].
Animal models and clinical studies established the involvement of glutamate and GABA neurotransmission in drug addiction.
Strouhal et al. (2003) have also established the involvement of proteins with heavy metal binding, sequestration and bioaccumulation in Yarrowia species.
The small but negative heat capacity change of the analogs along with the significant enthalpy entropy compensation phenomenon observed established the involvement of multiple weak noncovalent interactions in the binding process.
In this respect, our findings showing that the remaining vasopressor responses to DHE after ritanserin-pretreatment were attenuated by 10 and 30 μg/kg prazosin (Fig. 4a) and that they were markedly blocked by 100 and 300 μg/kg rauwolscine (Fig. 4b) establish the involvement of rauwolscine-sensitive α2-adrenoceptors and, to a lesser extent, of prazosin-sensitive α1-adrenoceptors.
A number of studies have also established the involvement of MAPKs in stem cell senescence.
We tried to establish the involvement of membrane-associated proteins in STPK mediated signaling.
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