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Thus, variegated loss of expression among the stably transfected L cell clones paralleled their expression pattern in transgenic mice, further establishing the function of the 3' intergenic region as a barrier element.
A technical problem with establishing the function of these proteins is that they are very stable, thus making them hard to deplete using methods such as RNA interference and the resulting phenotypes are not very informative because, as with some other components of centrioles their malfunctions leads to the activation of cell cycle checkpoints or apoptosis [2], [3].
This, and other strain sets, facilitated a wide range of systematic studies aimed at establishing the function of the genes, e.g. [ 4- 8].
It can help to transfer functional annotations from one species to another, to predict new complexes or to help in establishing the function of unknown human proteins within the cells.
For example, establishing the function of various buttons in the menu bar at the top of the quadrant view was a theme which reoccurred with a number of participants.
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Many kernels work by establishing the functions of antecedents to behavior.
These include scale worms, jellyfish and brittle stars but further research is needed to fully establish the function of the luminescence.
We have not yet established the function of wheeling in Cicindela dorsalis media.
These results provide the directions for the design of experiments to establish the function of PE and PPE proteins.
Investigating the domain architecture of a given protein and deriving its evolutionary origins is a starting point to establish the function of a novel protein.
References to publications that establish the function of the above query proteins are provided in those instances where original NCBI functional definition of the query proteins was either lacking or incorrect.
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