Sentence examples for establishing of concept from inspiring English sources

This method consists of the identification of clinically relevant research questions, followed by a systematic literature search, quality assessment, and summary of the evidence eventually leading to establishing of concept and final recommendations based on feedback from experts.

A wide variety of catalytic transformations have been established by artificial metalloenzymes, thus establishing proof of concept.

Therefore this novel line may provide a useful additional model for establishing proof-of-concept for new therapeutic concepts.

Here we achieved increased gene delivery by transgenic overexpression of CAR, a strategy that is suitable only for establishing proof-of-concept in animal models.

This study evaluated masitinib using in vitro and in vivo models of human pancreatic cancer, both as a single agent and in combination with gemcitabine, with the objective of establishing proof-of-concept.

This is a very important result establishing proof-of-concept for the use vorinostat to reactivate latent HIV.

Our approach draws heavily on principles of human-centered design, which puts target communities' needs and experiences at the center of program development and which incorporates iterative, short-cycle, rapid prototyping prior to pilot testing or establishing proof-of-concept.

Biomechanical tissue testing and finite-element modelling should complement each other, with experiments establishing proof of concept, and models supplying detail and optimising designs.

As discussed above, biomarkers can be valuable in selecting subjects for clinical trials and for therapeutic interventions, for reducing unexplained variance and thus improving statistical power, and for establishing proof of concept in early phase drug development.

Recent experimental studies have established proof-of-concept of such fuel cells and have also shown that their performance is greatly limited by poor fuel utilization.

These data establish proof-of-concept that masitinib can sensitise gemcitabine-refractory pancreatic cancer cell lines and warrant further in vivo investigation.