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While the focus of this study is solely on establishing methodology to improve screening hits, we are interested in the long run in improved MMP-14 inhibitors, so used this protein as a test case.
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We used pronuclear microinjection, which is a well established methodology in rats [11], for the establishment of shRNA-induced gene knockdown in this species.
Secondly, there has been no established methodology to correctly map spatial information extracted from history.
Once there is an established methodology to address this shortfall, then IVIVC studies may follow.
Studies adopting this method usually sampled by telephone: an established methodology, offering cheap and easy access.
The utilization of discrete-event simulation models is an established methodology for the analysis and planning of construction activities.
There is no established methodology for mapping the past territory of cities from text based historic information.
It is an established methodology for eliciting patient preferences in regards to treatment characteristics [17, 25, 34].
This group formulated recommendations, which were graded by all participants according to established methodology.
There is however no clearly established methodology for evaluating such adaptive interfaces.
Generalisations of the established methodology to allow for dynamic emulation are here proposed and contrasted.
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