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TJs are based on junction adhesion molecules (JAMs), claudins, occludin and other proteins, which represent important structural elements in establishing epithelial cell polarity.
They are often confused with the factor Lethal giant larvae (Lgl), which has a function in establishing epithelial cell polarity in animals [ 77, 78].
The recent discovery that several polarity complexes are conserved in mammalian cells and are closely associated with TJs indicates that TJs play a vital role in establishing epithelial cell polarity [ 19].
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A possible mechanism for ezrin to establish epithelial cell polarity.
EpCAM has meanwhile advanced to an established epithelial cell marker used in pathological examinations.
Here we show that ING1 translocates to the mitochondria of primary fibroblasts and established epithelial cell lines in response to apoptosis inducing stimuli, independent of the cellular p53 status.
To study the effects of stromal epithelial cell interactions on prostate cancer metastasis, we have used primary human prostatic stromal cells derived from malignant and non-malignant tissues and established epithelial cell lines from normal (PNT1a and PNT2-C2) and tumour (PC-3, DU145 and LNCaP) origins.
A plausible explanation is that epidermal keratinocytes are a type of established epithelial cells, and differentiation of this type of multipotent stem cells might require different gene regulation mechanism compared to that in pluripotent embryonic stem cells or in early embryogenesis.
Drosophila cbt was identified and characterized from an overexpression screen of EP lines conducted to determine genes involved in establishing epithelial planar cell polarity [ 6, 7].
The slime mold, Dictyostelium discoideum, has proteins related to β- and α-catenin (Aardvark and Ddα-catenin, respectively), which form a complex and are important in establishing epithelial-like cell polarity, along with Dictyostelium IQGAP (rgaA) and myosin II (Dickinson et al., 2012b; Dickinson et al., 2011; Grimson et al., 2000).
E-cadherin is a calcium-dependent cell-cell adhesion molecule playing a crucial role in establishing epithelial architecture and maintaining cell polarity and differentiation [ 10, 11].
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