Suggestions(2)
Exact(27)
Initial step in establishing efficacy of new antivirals is based on simple methods assessing inhibition of the intended target.
In central nervous system therapeutic areas, there are general concerns with establishing efficacy thought to be sources of high attrition rate in drug development.
Establishing efficacy through acceptable designs such as randomized controlled trials involves strict protocols to ensure meaningful internal validity but different approaches are needed to demonstrate meaningful effectiveness (external validity) outside the study setting.
Establishing efficacy is usually an important first step before widespread dissemination and implementation of new interventions.
Medical research remains dependent on model organisms and systems for establishing efficacy prior to the design of clinical trials.
Such RCTs are ideal for establishing efficacy; however, the control groups are unrealistic for modelling cost-effectiveness.
Similar(33)
The one exception is a report published in 2007 by the Institute of Medicine that stated that more research was needed to establish efficacy.
However, a randomized, controlled trial is required to establish efficacy.
Application is made to premixed and nonpremixed flames in one and two dimensions to establish efficacy.
A trial of redesigned units is required to establish efficacy (Trial Identifier: ISRCTN02681602).
Cardiac resynchronization therapy (CRT) has established efficacy for patients with systolic heart failure (HF).
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