Sentence examples for establishing cohesion from inspiring English sources

Both esco1 and esco2 (two homologs of yeast eco1) are responsible for establishing cohesion; thus, we wanted to determine whether loss of esco2 alone would have an effect on cohesion between sister chromatids.

A crucial event in establishing cohesion is acetylation by the Eco1 acetyltransferase of a pair of lysine residues (K112 and K113) on the surface of the Smc3's NBD (Ben-Shahar et al, 2008; Rowland et al, 2009; Unal et al, 2008), which occurs during S phase and is maintained until anaphase when it is removed by the Hos1 de-acetylase (Beckouët et al, 2010; Borges et al, 2010).

Upon entry into S-phase, as the sister chromatids are being synthesized, the two establishment of cohesion factors, ESCO1 and ESCO2, establish cohesion by securing the cohesin ring around sister chromatids (Skibbens et al., 1999; Hartman et al., 2000; Homer et al., 2005; Skibbens, 2009; Terret et al., 2009).

Cohesin is loaded on chromatin in early G1 in vertebrate cells and establishes cohesion during S phase [4], [5].

In budding yeast, the acetyltransferase Eco1/Ctf7 establishes cohesion during DNA replication in S phase and in response to DNA double strand breaks in G2/M phase.

Both Smc3 acetylation and Scc1 acetylation appeared to counteract the function of Wapl to establish cohesion.

Ctf7 establishes cohesion during S phase, and interacts with components of the DNA replication machinery, including PCNA and RFC [ 5- 7].

Cohesin-DNA complexes in eco1∆ wpl1∆ cells are stably bound to DNA but fail to establish cohesion, indicating a post-DNA binding step is required for cohesion.

Only 63% mps3 ∆ pom152 ∆ cells established cohesion, which is similar to the amount of cohesion observed in mps3 ∆75–150 mutants (64%) (Ghosh et al. 2012).

Consistent with this idea, cohesin, which established cohesion in S phase, has been reported to be removed genome-wide upon DNA damage in G2/M (McAleenan et al. 2013).

The SMC-1/ 3 "cohesin" complex establishes cohesion between sister chromatids, while the SMC-2/ 4 "condensin" complex mediates chromosome condensation and resolution.