Sentence examples for establishing cell cycle from inspiring English sources

These observations indicate that if integrity of the p19ARF/p53 pathway is crucial for establishing cell cycle arrest in FHL2−/− cell lines upon Ras expression, inactivation of Rb by increased cyclin/Cdk activity may be sufficient to reset their replicative lifespan.

These kinase genes include CCRK which is established cell cycle related kinase [69], MASTL which is a relatively unknown kinase gene associated with mitosis through co-expression analysis and NEK6 which is also an established mitosis related kinase [70].

The diminished H3K9me1 tended to increase in the established cell cycle-specific G9a expressing cell lines (Figs 5a and S3).

Before trying to establish cell cycle-specific G9a expressing cells, we examined endogenous G9a protein level in different cell cycle in iMEFs.

We have implicated several established cell cycle-arrest genes in XY germ cell G1/G0 arrest.

p27 inhibits Cdk2-cyclin A activity and establishes cell-cycle arrest in G1, whereas p21 broadly inhibits Cdk-cyclin complexes and elicits arrest at various stages.

We evidenced this hypothesis by sorting cells from the DAPI- or Hoechst-labeled GSCs of the first and second peaks of the DNA histogram (Fig. 6B and C, respectively), by determining whether they were singular or doublet cells by immunostaining (Fig. 6D), and by establishing their cell cycle phase based on their fusome morphology (Fig. 6E– E').

In yeast, the GTPase Cdc42p, together with its GTP exchange factor Cdc24p and its target Ste20p, is required to establish cell polarity during the cell cycle and is involved in cellular responses to mating pheromone and to nutritional limitation [ 44].

In turn, the plant produces GA, which seems to combat the improper growth signals and re-establishes cell-cycle control.

It is well established that cell cycle progression is dynamically and strictly regulated by complexes containing cdks and cyclins all of which are critical for the normal progression of cell cycle and inactivation of these proteins leads to cell cycle arrest [24], [25], [26].

It is well established that cell cycle is linked to cell proliferation and apoptosis [ 14, 15].