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Long-term, randomized, controlled population-based trials — the gold standard for establishing benefit — prove that mammography can reduce breast cancer mortality as much as 32percentt among women ages 40 to 70 years at entry into screening.
Establishing benefit is difficult if only one component of a composite endpoint responds to the treatment.
Moreover, the criteria for establishing benefit or side effects of treatment strategies in this population are uncertain and not well recognized.
But the device was introduced without clinical trials establishing benefit, and in the ensuing years much debate as regards its safety and efficacy has occurred.
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Many would agree that n of 1 trials do not represent research, but (only) the highest standards of establishing benefits and harms of therapy in an individual.
A new evidence base is needed, including new approaches to (for example) establishing benefits entitlement, which locates recovery as a subjective experience rather than as an observable state.
The most established benefit of forest cover is in controlling erosion and downstream sedimentation.
To evaluate whether the previously established benefit of blue light filtering intraocular lenses (IOLs) when driving in glare conditions is maintained in patients previously implanted with a blue light filtering toric IOL.
In California and in six other states, there are already laws in place that establish "benefit corporations" (the legal term for B Corporations) as a new way to organize a business.
This could have negatively affected the established benefit of KMC to their infants.
A large randomized controlled intervention trial would be needed to establish benefit.
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