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Using molecular biology approaches, we demonstrate that ectopic expression of META1 and site-directed mutagenesis of selected residues in the predicted META1 cavity do affect secretory processes in Leishmania, thus establishing a function for this poorly characterized protein as well as identifying a functional domain within the molecule.
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The government is working on establishing a functioning asylum system.But the incentives pushing migrants north haven't changed.
Early aspirations to bring peace, prosperity and decent government to the country have been replaced by the hope of establishing a functioning state and of improving security.
The report notes that little progress has been made in reforms; administration and rule of law remain weak; the position of minorities unsatisfactory; and little progress has been achieved in establishing a functioning market economy.
Naturally the first step for the next Guinean president will have to deal with establishing a functioning judiciary, and work toward the extremely ambiguous topic of reconciliation in order to move forward.
There is little question that establishing a functioning nation-state in Afghanistan is a critical objective to enhancing the stability and security of this volatile region, with Iran in foreshortened revolutionary tumult to Afghanistan's west and Pakistan in its never-ending dysfunction to its east.
Health Programme -- Health management committees The intervention has made advances in establishing a functioning organisational structure at parish level in the PDC, which has the potential to make a significant impact on the participation of women in decision making.
The plates were cultivated for 24 h, and numbers of viable colonies were counted to establish a function of percentage reduction versus contact time in minutes.
"It's clear beyond a shadow of a doubt that they've established a function" for PrP, says Neil Cashman, a neuroscientist at the University of British Columbia in Vancouver, Canada.
It is not possible to establish a function based on annotation, and, in some cases, even to find homologues for a number of genes induced during organogenic nodule formation.
But we also do it to re-establish a functioning marketplace in the communities.
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