Sentence examples for establishes proof of concept from inspiring English sources

This paper establishes proof of concept that computational modeling can emulate the performance of physical testing laboratories for heat of hydration and compressive strength testing of type I, II and III portland cements.

This initial method establishes proof of concept for a morphology-based cell evaluation approach, but reveals a practical limitation when considering the need to handle large amounts of image data.

This study establishes proof of concept and will inform an adequately powered multicentre trial to definitively examine the efficacy and safety of ethanol locks as an alternative to current therapies used in the prevention of catheter-associated blood stream infections in patients dialysing with tunnelled catheters.

Recent experimental studies have established proof-of-concept of such fuel cells and have also shown that their performance is greatly limited by poor fuel utilization.

We also describe the role of PD analyses in clinical trials, including for MOA confirmation and dosage regimen optimization during phase 0 trials as well as for correlating molecular changes with clinical efficacy when establishing proof-of-concept in phase I/II trials.

Therefore this novel line may provide a useful additional model for establishing proof-of-concept for new therapeutic concepts.

These data establish proof-of-concept that masitinib can sensitise gemcitabine-refractory pancreatic cancer cell lines and warrant further in vivo investigation.

Here we achieved increased gene delivery by transgenic overexpression of CAR, a strategy that is suitable only for establishing proof-of-concept in animal models.

This study evaluated masitinib using in vitro and in vivo models of human pancreatic cancer, both as a single agent and in combination with gemcitabine, with the objective of establishing proof-of-concept.

Recently completed trials have compared the paediatric formulations of the candidate vaccines RTS,S/AS02D and RTS,S/AS01E in children aged 18 months to 4 years from Gabon [8], assessed RTS,S/AS02D when coadministered with EPI antigens in infants from Tanzania [9] and established proof-of-concept of RTS,S/AS01E in children aged 5 to 17 months from Kenya and Tanzania [10].

This is a very important result establishing proof-of-concept for the use vorinostat to reactivate latent HIV.