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The manuscript in its present form thus establishes a proof of principle for critical resting activity, which lays the groundwork for future studies of avalanche dynamics at the cellular level, including during active information processing.
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These data collectively suggest that the CPP is a novel approach to suppressing the growth of cancer cells while sparing normal cells and thereby establishes a proof-of-concept that blocking YB-1 activation is a new course of cancer therapeutics.
Our findings in vitro and in vivo, including the use of a small molecule inhibitor of IRE1α to retard PCa growth, establishes a proof-of-principle for such studies in the future.
Candida albicans biofilm growth on the toremifene-release side is significantly inhibited, establishing a proof-of-concept for the drug delivery functionality of mesoporous SiO2 incorporated into a high-strength macroporous Ti carrier.
We therefore establish a proof-of-principle that blocking P-YB-1S102 P-YB-1S102 P-YB-1S102or cancer therapeutiss.
These findings establish a proof-of-principle for applications of autologous iPSCs for the safe and effective treatment of retinal degenerative diseases.
These studies should be highly informative to establish a proof-of-concept for AIDS gene therapy, and will facilitate evaluation and improvement of vectors being considered for clinical applications.
We establish a proof-of-concept that whole genome sequencing can be used to identify single nucleotide polymorphisms between S. cerevisiae strains, which can be subsequently linked with particular phenotypes of interest (Figure 1).
However, such post-hoc simulation to establish a "proof-of-concept" is a typical first step in evaluating potential computer-based testing procedures [ 14, 18, 19, 21].
Having established a proof-of-principle that eIF2B can be pharmacologically modulated, now enables directed screening efforts to identify new series of compounds and thereby enhance the probability of developing clinically useful pharmaceuticals that address currently unmet needs.
Together, these findings establish a proof-of-concept that macrolides with more potent invasion inhibitory activity can be developed through chemical modification and that the dual activities of invasion inhibition and other inhibitory activities can be developed in single compounds and are not mutually exclusive.
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