In the past two decades, a large number of experimental studies have established a pathological role for Aβ in AD [1] [2].
In the past several years a large body of evidence has established a pathological role for β-amyloid polypeptide (Aβ) in AD [5] [10].
Here, CNP obtained from human tissues were inoculated into laboratory animals and cell cultures in order to establish a pathological role for these particles [30], [34], [38], [52], [53].
Until recently, only a few hundred prosopagnosics had been studied, and from this research neuroscientists and perceptual psychologists had established a binary "pathological" model: either you were normal, and could recognize faces, or you had face blindness.
Together, these findings establish a novel pathological pathway that unifies maternal and embryonic causes of RPL.
To establish a diagnosis, pathological confirmation is required.
In 1988, the International Federation of Gynecology and Obstetrics (FIGO) established a new pathological and surgical staging system for endometrial cancer.
Another report showed that EUS-FNA failed to establish a specific pathological diagnosis other than lineage determination in one-third of cases evaluated 20.
The inability to establish a clear pathological basis for dementia led some to incorporate it into a psychodynamic approach that emphasized external factors in the development of mental illness: privileging mind over matter, and focusing on family upbringing, personal stress and environment (Micale, 2002: 310; Ballenger, 2006: 36–56).
It satisfies the practical requirements of physicians and establishes a productive heuristic for subsequent pathological and etiological inquiry, since "the value of every diagnosis is thus rated essentially by the extent to which it opens up reliable prospects for the future" (1899, 4).
