Sentence examples for established whether these changes from inspiring English sources

Studies to date however have not established whether these changes are correlated with increased survival in humans or animal models that have cardiomyopathy as the primary defect.

It remains to be established whether these changes in intracellular volume also occur in cells growing in tissues, and if so, what triggers them, what mechanisms are responsible for their regulation, and what, if any, is the importance to the physiology of the cell.

However, it remains to be firmly established whether these changes are causal or secondary to physiological changes or perhaps pharmacologically induced.

We seek to establish whether these changes in regulations are important in explaining the reduction, over the past two decades, in day trips from the US into Mexico (and back).

To establish whether these changes were specific to hemangiosarcoma, or if they were simply associated with any malignancy, we compared array data from six hemangiosarcoma samples with data from five osteosarcomas, three leukemias, and 13 non-Hodgkin lymphomas.

For example, SARM1 appears to act downstream of reactive oxygen species accumulation, ATP depletion, and Ca2+ influx when cell death and axon degeneration are induced by the mitochondrial toxin carbonyl cyanide m-chlorophenyl hydrazone (CCCP) (Summers et al., 2014), but it will be important to establish whether these changes also occur downstream of NMNAT2 loss during WLDS-sensitive degeneration.

Although some miRNAs have been shown to exert a disruptive effect on skeletal muscle differentiation at least in cell culture models [ 70], in most cases, it remains to be established whether the changes in miRNA expression levels are causally involved in these diseases or are secondary to the degeneration/regeneration response of the affected muscle tissue.

To establish whether the changes in growth and apoptosis induced by DCA correlated with reduced glycolysis, we measured lactate levels in growth media.

We next sought to establish whether these allele-specific changes in GATA2 methylation and expression are accompanied by changes in chromatin structure at the promoter.

The present study has only assessed effects on mRNA expression, and it will be important to establish whether these translate into changes in protein levels and activities of these enzymes.

Therefore, it remains to be established whether similar changes in LpPLA2 activity would occur with glucose lowering.