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Although it remains to be established whether the effect of LDLR on Aβ metabolism is apoE dependent, this finding identifies another apoE endocytic receptor that modulates Aβ metabolism in the brain.
We next established whether the effect of the autoantisera upon the SRP-dependent targeting reaction could be reproduced using purified autoantibodies.
We next established whether the effect of PDT on tumours outside the treatment field was dependent upon adaptive immune cells by examining the ability of PDT to control the growth of tumours present outside the treatment field in immuno-compromised SCID mice, which lack T and B cells.
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To establish whether the effect of FBS on GLUT4 was due to an increase in exocytosis or to a reduction in internalization, GLUT4 internalization was measured (Figure S2).
Future research is needed to establish whether the effect we documented is specific to semantic processing or can be generalised to language.
Finally, in the third stage, we performed a mediation analysis to establish whether the effect of perceived responsiveness on romantic interest was mediated by affective presence.
Further research is clearly required to establish whether the effect of Black ethnicity is indeed more marked in ER-positive than ER-negative disease, and if so whether this is related to the use or effectiveness of Tamoxifen.
23 Finally, to establish whether the effect of each treatment was similar for different socioeconomic groups, we carried out a test for interaction between the index of multiple deprivation and each treatment effect for the primary outcome.
To establish whether the effect of the applied chemicals on freezing tolerance was mediated by ABA, the expression of the gene encoding 9-cis-epoxycarotenoid dioxygenase (NCED1), the regulatory enzyme of ABA synthesis was measured.
It would be interesting to establish whether the effect of MED13 on cardiac metabolism impacts on the function of cardiomyocytes and why MED13 differentially affects the cardiac muscle and peripheral organs.
A drug dose of 30 mg/kg combined with radiation produced a greater tumour response than either agent alone, but it was not possible to establish whether the effect was more than additive.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com