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However, it remains to be established whether activation of c-Jun/ATF2 leads to an enhanced level or activity of the genes identified by DNA microarray.
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We next sought to establish whether activation of cell stress pathways in YFP-expressing neurons had any adverse effects on neuronal morphology.
In order to establish whether activation of the PI3-K/Akt pathway was involved in the upregulation of PPARγ-dependent gene expression, we tested the effects of the PI3-K inhibitor LY294002 on the expression profile of downstream effectors, such as LXRα and ABC sterol transporters in THP-1 macrophages.
Thus, to establish whether activation of the PI3K/Akt pathway was also integral to the ProMyoAAV-induced increase in muscle glucose disposal, we analyzed phosphorylation and total protein levels of key signaling intermediates in muscle lysates by Western blotting.
Furthermore, up to now it has not been established whether the activation of the ANS during motor imagery is specific to the action being imagined.
The first objective of Experiment 2 was to establish whether automatic activation of attitudes toward body-related primes remained when a set of normatively- rather than individually- selected body-related primes was used.
Based on this line of reasoning, our broad goal is to establish whether reflex activation of the cervical multifidus muscle contributes to straining the facet capsular ligament and thereby contributes to the genesis of whiplash injury.
Surprisingly, no prior study has established whether EGFR-mediated activation of DNA-PK is a protective pathway that operates during brain injury.
Having established that activation of CD28 enhances the activity of AMG 330 in leukemic cell lines, we aimed to assess whether activation of CD28 also impacted the efficacy of BiTE antibody constructs against primary patient leukemia cells.
It is well established that activation of inflammatory cells determines the severity of pancreatitis.
Some of the important questions to be addressed relate to compartmentalisation of signaling events to establish whether, for example, activation of PI3K and/or mTOR by insulin is confined to a specific location and whether mTOR activated by ET-1 constitutes a distinct pool.
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CEO of Professional Science Editing for Scientists @ prosciediting.com