Sentence examples for established their efficacy from inspiring English sources

Thiazide diuretics have carved out a preponderant position in the therapeutic arsenal against arterial hypertension thanks to clinical trials which have established their efficacy [204].

Although both saxagliptin and sitagliptin are FDA approved and have established their efficacy through clinical trials [15], little is known about their comparative effectiveness in the real world; more research is needed to measure the impact on cost and resources use [16].

The sequences of translation-blocking MASOs directed against SpWnt8 (GTACACTCCAATAAAAGAAATCAAA) and SpCyclinD (TATCCATGATTGATAGAAGACGTTC) were obtained from previous studies that established their efficacy [49], [50].

Thiazide diuretics have carved out a preponderant position in the therapeutic arsenal against arterial hypertension thanks to clinical trials which have established their efficacy [ 204].

Despite these recent conflicting findings, the protective effects of these agents are well established (their efficacy is further evaluated in another review in this supplement [ 54]).

Recent treatment modalities that have established their efficacy in patients with severe sepsis include drotrecogin alfa (activated) [ 5] and early goal-directed therapy [ 7].

However, three promising polyanionic compounds recently failed to pass phase III clinical trials designed to establish their efficacy in preventing HIV acquisition.

Further studies of these compounds in experimental animal models and in prospective randomized clinical trials will help to establish their efficacy in donor pretreatment.

The antiviral properties of plants are rarely studied using laboratory-based assays to establish their efficacy in traditional medicine [ 6, 15].

Although considerable evidence supports the use of GLP-1 receptor analogs in critically ill hospitalized patients with hyperglycemia, well-designed prospective studies comparing these agents with insulin will be required to establish their efficacy and safety.

It is important to note the recommendations they propose under "incretin-based approach" with these agents represent their opinion for use and, as they point out, well-designed prospective studies comparing these agents with insulin will be required to establish their efficacy and safety.