Exact(1)
Other investigators have established the selectivity and potency of sirtinol as a selective SIRT1 inhibitor by showing that its biological effects are faithfully mimicked by SIRT1 siRNA and that it can neutralize the actions of pharmacological SIRT1 activators [22].
Similar(59)
However, to establish the selectivity of this uptake, more studies are required.
Because a typical voxel contains many thousands of neurons with varied properties, establishing the selectivity of their responses directly is impossible.
The interference effects of various closely related foreign ions on the displacement reaction were found to be negligible, thus establishing the selectivity of the proposed technique over other standard analytical techniques available for the estimation of iron III).
Extensive biochemical, cellular, and pathway-based profiling establish the selectivity of JNK-IN-8 for JNK and suggests that the compound will be broadly useful as a pharmacological probe of JNK-dependent signal transduction.
Piracetam and levetiracetam separation was measured in term of resolution factor of the peaks which in turn establish the selectivity of the method.
To further establish the selectivity of zoospore phototaxis, we inhibited carotenogenis by growing Blastocladiella for three generations in the presence of the inhibitor norflurazon [ 29].
To establish the selectivity of GDIs towards Rab proteins further, the interaction of Rab4A, which has been reported to be involved in GLUT4 recycling [ 28, 29], with both GDIs was also tested using both immunoprecipitation and in vivo FRET.
PTKs have sequence-specific kinase activities and relatively short peptides have been used to establish the selectivities of large panels of kinases [2].
It was established that the selectivity between the tungsten surface and the SiO2 surface could be enhanced through the oxidation of the tungsten surface.
In this subset of dogs (n = 6), surgery was performed 4 6 hours post administration of RGD-A-TNF, this same-day experimental subset was designed to establish the acute selectivity of RGD-A-TNF trafficking and its tumor vascular localization.
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