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However, once this rather abstract principle is established, the question still remains unanswered.
One starts with the basic fact that Oscar was Mourinho's first choice, ahead of Mata, in the playmaking role, and once that is established, the question is whether it is prudent to keep an asset worth £37m on the bench.
Once effective detection methods have been established, the question becomes: what kind of behavior does the system adopt after detection?
While the phylogeographic correlation of the mtDNA haplogroups and geographic origins is very well established, the question of whether the distribution of human mtDNA haplogroups is the result of adaptation to the environment or the result of random genetic drift with some modification by purifying selection is still under debate[2].
Once a diagnosis of bipolar affective or a related disorder is established, the question of which mood stabilizer to use as maintenance therapy arises.
Once the order in which the PC should be added to the model is established, the question is how many PC should be used in the subsequent PCR model used for genomic prediction.
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Until definitive relationships between genetic or environmental variation and drug response can be established, the questions of why some women develop high body temperature, and why so many high fevers occurred in Ecuador, remain.
Additionally, legal tools applied on the study area are provided to pose the effects of legal impediments and to establish the question of law.
The method is divided in four phases: 1) establishing the questions; 2) planning the focus groups (number and size of groups, time and place of meetings, selection and recruitment of participants, choice of moderator); 3) leading of the focus group; 4) analysis and report.
But, once the casting or production concept have been established, the next question is whether the words will serve them.
Once this is established, the next question is what incentives and disincentives - or, to give them their politically incorrect names, what bribes and punishments - are most appropriate.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com