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Once the xenografts were established, the mice were divided into five groups of ten mice, with equivalent mean tumour volumes for each group.
When the tumors were established, the mice were randomly assigned and treated with STAT3 decoy or scramble ODN (intratumoral injection daily).
To characterize the A12-specific T-cell response that develops within an inflammatory milieu, DR1 mice were immunized with CII/CFA, and once arthritis was clearly established, the mice were treated subcutaneously with A12 peptide.
After tumors were established, the mice were divided into four groups randomly, which received normal saline (vehicle, 100 ul i.p. 2/week; n=5), YM155 (10 mg/kg i.p. twice per week; n=5), docetaxel 20 mg/kg per week and combined docetaxel and YM155 infusion.
After the tumors were established, the mice were divided into two groups randomly, which received YM155 (10 mg/kg i.p. twice per week; n=5) or normal saline (vehicle, 100ul i.p. 2/week; n=5) infusion for 3 weeks for xenograft and 2 weeks for orthotopic tongue tumors, respectively.
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Large scale international activities for systematic conditional mouse mutagenesis, exploiting advances in the sophisticated manipulation of the mouse genome, has established the mouse as the premier organism for developing models of human disease and drug action.
RVNT established the mouse embryonic fibroblasts and performed the TMRE and ROS measurements.
We established the mouse PCLS system using perfluorodecalin (PFD) as an artificial oxygen carrier.
In 2003, Karen Steel joined the Wellcome Trust Sanger Institute, where she established the mouse genetics project that aims to generate and characterise knockouts ultimately for every gene in the mouse genome.
Together with recent advances in the manipulation of the mouse genome, this information has established the mouse as the premier organism for developing models of human disease and drug action (2).
After 7 days of preventive treatment, mice were subjected to lateral ventricle injection of Aβ25-35 Aβ25-35blish toestablishdel of Alzheimer's disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com