Sentence examples for established the functional importance from inspiring English sources

Previous work in vinorine synthase [ 6] has established the functional importance of the Cys residue in the QVTX(F/L XCGG motif.

Now that we have established the functional importance of EZH2 expression in BRCA1-deficient cells, it would be interesting to understand why these tumors are selectively dependent on EZH2, and whether this dependence is specific to loss of BRCA1 function, or more related to the basal-like characteristics of these tumors.

To establish the functional importance of target-site localization in the 3' UTR, we modified the stop codon to extend the coding region of the transgene reporter through the miRNA target sequence.

We establish the functional importance of PKA anchoring in multiple aspects of DC biology using the anchoring inhibitor peptides Ht31 and AKAP-IS.

To address this apparent discrepancy we have now extended our studies in two ways: (1) we evaluated hippocampal neurophysiology, memory and cognition to establish the functional importance of the neuropathologic endpoints; and (2) we assessed whether microglia affect conversion of monomeric Aβ to oligomer form, a key step towards cognitive dysfunction and subsequent fibril formation [12], [13].

In order to establish the functional importance of Bim in the GC-induced killing of CLL cells, we used siRNA to prevent GC-induced Bim upregulation.

To establish the functional importance of gB-NT, we introduced one of three deletions, removing amino-acid residues 2 6, 2 14 or 2 30 after the predicted MuHV-4 gB signal sequence.

However, it has been challenging to establish the functional importance of NMDA-Rs specifically in DA neurons for cocaine-induced synaptic AMPA-R potentiation, as opposed to a possible indirect process involving NMDA-Rs on other cell types.

We next sought to establish the relative functional importance of Aurora kinase phosphorylation of Lgl in vivo.

First, the functional importance of the cytoskeleton was established with whole-cell patch clamp experiments recording ENaC reconstituted in CHO cells.

Lastly, the functional importance of these markers remains to be established, since mAb neutralizing PD-L1 in CLL patients does not efficiently abrogate T-cell suppression, which is instead induced by IDO inhibitor.