The methylome GigaDB page also includes data and associated files that do not have equivalent established repositories.
At the end of his talk, Dr. Schick mentioned established repositories for the collection and distribution of relevant mutant strains essential for basic biomedical research.
However, nowadays very large datasets (i.e., file size on the order of a few terabytes) can also be generated in MS-based proteomic and metabolomic studies, and can be submitted to established repositories.
The complementary system of releasing data through GigaDB and established repositories also has the advantage of making the data available much sooner than the staggered build releases of many of these databases, which can take several months.
Requiring authors to submit microarray data to the public databases will provide a number of distinct advantages to the entire research community: These established repositories have a commitment to continued community service and to providing some level of assurance that published gene expression data sets will continue to be available into the future.
The Lyme Disease Research Foundation has also helped establish repositories of blood and tissue samples from patients with Lyme disease at Johns Hopkins, providing researchers with opportunities to collaborate in the search for disease biomarkers that could lead to improved diagnostics and treatment.
In 1996, they set up a foundation, PXE International, found 2,000 patients, established a repository of patients' tissue, raised money and enlisted scientists.
Committee participant William Pao, an associate professor at the Vanderbilt-Ingram CaNashvilleer in Nashville, Tenn., has established a repository of tissue specimen samples from nonsmokers with lung cancer as a first step in such a study.
NIDDK has established a repository for the archiving of data sets, as well as genetics and tissues from NIDDK sponsored clinical trials and epidemiological studies (http://pubnts06.rti.org/niddk/home.do).do
For materials such as mutant strains and cell lines, Scientific Data requires authors to use established public repositories when one exists, and provide accession numbers in the manuscript.
