Sentence examples for established proof of concept from inspiring English sources

These studies established proof of concept that F3284-8495 could be used as a favorable chemical scaffold for development of HIV RNase H inhibitors.

This study established proof of concept and rationale for proceeding to testing of different DENV PIV tetravalent formulations in phase 1 clinical trials.

This was based on an established proof of concept by Langer where they grew an outer ear from bovine chondrocytes and an ear-shaped scaffold on the back of a mouse (Cao et al., 1997).

Recent experimental studies have established proof-of-concept of such fuel cells and have also shown that their performance is greatly limited by poor fuel utilization.

Recently completed trials have compared the paediatric formulations of the candidate vaccines RTS,S/AS02D and RTS,S/AS01E in children aged 18 months to 4 years from Gabon [8], assessed RTS,S/AS02D when coadministered with EPI antigens in infants from Tanzania [9] and established proof-of-concept of RTS,S/AS01E in children aged 5 to 17 months from Kenya and Tanzania [10].

New experimental research designed to model low-dose exposure relevant to vaccines has established proof-of-concept that Thimerosal-Hg has the potential to produce nonclinical effects in the central nervous system [ 17] not contemplated by AEFI.

Such trials have more recently established proof-of-concept for protection by postconditioning and remote preconditioning in elective and emergency I/R settings; of note, this success was related to mechanical strategies or to established, no longer patent-protected drugs where there was no involvement of pharmaceutical industry.

We also describe the role of PD analyses in clinical trials, including for MOA confirmation and dosage regimen optimization during phase 0 trials as well as for correlating molecular changes with clinical efficacy when establishing proof-of-concept in phase I/II trials.

Therefore this novel line may provide a useful additional model for establishing proof-of-concept for new therapeutic concepts.

These data establish proof-of-concept that masitinib can sensitise gemcitabine-refractory pancreatic cancer cell lines and warrant further in vivo investigation.

Here we achieved increased gene delivery by transgenic overexpression of CAR, a strategy that is suitable only for establishing proof-of-concept in animal models.