Sentence examples for established mutation from inspiring English sources

Reversion of the established mutation, also referred as rescue experiments, is critical for functional confirmation of targeted genes.

Once this has been established, mutation analysis for the selection of patients for whom anti-EGFR therapy will be beneficial presumably has to be extended to KRAS exon 3, PIK3CA, BRAF and NRAS.

The non-recombining nature of this chromosome region as well as the availability of a reliable molecular clock, through the established mutation rate of STRs, allows a chronological reconstruction of haplotype genealogy, when these different types of markers are analysed jointly [14] [17].

Mutations arise according to the established mutation rate and their effects are not selected a priori.

Patients were categorised into established mutation groups according to their genotype with the less severe mutation determining the group (9).

When mutations arise sequentially, each established mutation also reaches fixation; hence F ∼ 1 for small habitats, L ≪ Lc.

Beside the seven most established mutations, one unusual codon 12 mutation (GGT>TTT, Gly to Phe) was identified.

Tertiary HPT was found in one female patient with no established mutations in any of the known genes.

For weaker bottlenecks, most established mutations should typically survive the bottleneck and hardening will generally be unlikely.

Here, we define genetic architecture as the number of, and physical distances between, loci contributing to local adaptation, and the distribution of selection coefficients of established mutations.

Whole-exome sequencing in the meantime has become a feasible alternative to identify established mutations as a cause of hereditary renal disease, and to identify mutations that expand the phenotypic spectrum of single-gene disorders.